Heridity( Genes, DNA And Cancer)

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Do we really inherit these cancer genes? The vast majority of cancers are non-hereditary ("sporadic cancers"). Hereditary cancers are primarily caused by an inherited genetic defect. Less than 0.3% of the population are carriers of a genetic mutation which has a large effect on cancer risk and these cause less than 3–10% of all cancer. Some of these syndromes include: certain inherited mutations in the genes BRCA1 and BRCA2 with a more than 75% risk of breast cancer and ovarian cancer, and hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome) which is present in about 3% of people with colorectal cancer, among others.

DNA and Genes Inside almost every single cell in your body is a structure called the nucleus, which is the control centre of the cell. Inside the nucleus are 23 pairs of chromosomes. These are long strings of DNA.
DNA stands for deoxyribonucleic acid (pronounced dee-oxy-rye-bow-nu-clay-ik acid). Each string of DNA is shaped like a twisted ladder, which is called a double helix.

You have more than two metres of DNA inside every cell, but it is very tightly coiled up so it all fits. DNA can be thought of as a code, containing all the instructions that tell a cell what to do. It is made up of genes. Humans have around 25,000 genes in total.

You inherit half your DNA from your mother and half from your father, so you have two copies of every gene. Your genes carry all the information that makes you, you. They tell your body to have blonde hair, or brown skin, or green eyes for example. And they tell your cells what sort of cell to be, how to behave, when to grow and reproduce, and when to die.
Some genes control how much each cell grows and divides.

How faulty genes lead to cancer Our genes pick up mistakes that occur when cells divide. These mistakes are called faults or mutations and happen throughout our lives. They are caused by the natural processes in our cells, and by various other factors. These include
• Tobacco smoke
• Radiation
• Ultraviolet radiation from the sun
• Some substances in food
• Chemicals in our environment

Sometimes people inherit certain faulty genes from their parents that mean they have an increased risk of cancer. Usually, cells can repair faults in their genes. If the damage is very bad, they may self destruct instead. Or the immune system may recognise them as abnormal and kill them. This helps to protect us from cancer.
But sometimes mutations in important genes mean that a cell no longer understands its instructions, and starts to multiply out of control. It doesn't repair itself properly, and it doesn't die when it should. This can lead to cancer.

There are four main types of gene involved in cell division. Most tumours have faulty copies of more than one of these types.

Genes that encourage the cell to multiply (oncogenes) Oncogenes are genes that, under normal circumstances, play a role in telling cells to start multiplying and dividing. Normally, in adults, this would not happen very often. We can think of oncogenes as being a bit like the accelerator pedal in a car. When they are activated, they speed up a cell's growth rate. When one becomes damaged it is like the accelerator becoming stuck down. That cell, and all the cells that grow from it, are permanently instructed to divide. So a cancer develops.

Genes that stop the cell multiplying (tumour suppressor genes) Usually, cells can repair faults in their genes. If the damage is very bad, genes called tumour suppressor genes may stop the cell growing and dividing. Mutations in tumour suppressor genes mean that a cell no longer understands the instruction to stop growing and starts to multiply out of control. This can lead to cancer. The best known tumour suppressor gene is p53. The p53 gene is damaged or missing in most human cancers.

Genes that repair other damaged genes (DNA repair genes) The DNA in every cell in our body is constantly in danger of being damaged. But cells contain many different proteins whose job is to repair damaged DNA. Thanks to these, most DNA damage is repaired immediately, with no ill effects. But if the DNA damage occurs to a gene that makes a DNA repair protein, a cell has less ability to repair itself. So errors will build up in other genes over time and allow a cancer to form. Scientists have found these genes to be damaged in some human cancers, including bowel cancer.

Genes that tell a cell to die (self destruction genes) Some genes normally tell a cell to self destruct if it has become too old or damaged. This is called apoptosis or programmed cell death. It is a highly complex and very important process. Cells usually die whenever something goes wrong, to prevent a cancer forming. There are many different genes and proteins involved in apoptosis. If these genes get damaged, a faulty cell can survive rather than die and it becomes cancerous.

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